CD3D - CD3 delta subunit of T-cell receptor complex Gene

Also Known as T3D; IMD19; CD3DELTA; CD3-DELTA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 915

About CD3D

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,338,954-118,342,705 (from NCBI)

This gene has 8 transcripts (splice variants), 146 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 30.2), appendix (RPKM 14.7) and 9 other tissues.

Summary

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four Other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

CD3D Products (2)

mRNA	Protein	Name
NM_000732.6	NP_000723.1	T-cell surface glycoprotein CD3 delta chain isoform A precursor
NM_001040651.2	NP_001035741.1	T-cell surface glycoprotein CD3 delta chain isoform B precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	14967045	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of T cell receptor complex	IDA IDA: Inferred from direct assay	8176201	GOA
part of alpha-beta T cell receptor complex	IDA IDA: Inferred from direct assay	9485181	GOA
part of alpha-beta T cell receptor complex	IPI IPI: Inferred from physical interaction	31461748	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	31461748	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD3D Protein Structure

ITAM

0
100
171 a.a.

Protein Preferred Names	Protein Names
T-cell surface glycoprotein CD3 delta chain	CD3 antigen, delta subunit

CD3D Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CD3D	P04234	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	CD3D	P04234	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	CD3D	P04234	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD3D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7879	CD3D Protein, Human (HEK293, His)	P04234-1 (F22-A105)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70434	CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc-Flag&Fc-His)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72726	CD3D-CD3E Heterodimer Protein, Human (HEK293, His)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73498	CD3D-CD3E Heterodimer Protein, Human (HEK293, Flag-His)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77610	CD3D-CD3E Heterodimer Protein, Human (HEK293, Fc)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P77612	CD3D-CD3E Heterodimer Protein, Human (Biotinylated, HEK293, Fc-Avi)	P04234-1 (F22-A105)&P07766 (D23-D126)	≥ 95%, as determined by Bis-Tris PAGE.

CD3D Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80600	CD3D Antibody (YA539)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P80600A	CD3D Antibody (YA539)(PBS only)	WB, IHC-F, IHC-P, ICC/IF, IP	Human
HY-P83942	CD3D Antibody (YA3639)	WB, FC, ELISA	Human
HY-P83942A	CD3D Antibody (YA3639)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 19	IMD19 Cd3-Delta Deficiency Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Cd3delta Deficiency Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Immunodeficiency 19, Severe Combined Cd3d Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency Immunodeficiency, Type 19
T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta	T-B+ Scid Due To Cd3delta/Cd3epsilon/Cd3zeta
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Immunodeficiency 18	IMD18 Cd3-Epsilon Deficiency Immunodeficiency 18, Scid Variant Cd3epsilon Deficiency Immunodeficiency 18, Severe Combined Immunodeficiency Variant Immunodeficiency, Type 18
Immunodeficiency 17	IMD17 Cd3-Gamma Deficiency Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive Combined Immunodeficiency Due To Cd3gamma Deficiency Immunodeficiency 17, Cd3 Gamma Deficient Cd3gamma Deficiency Immunodeficiency, Type 17
Cd3zeta Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive, 3	CGD3 Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii Granulomatous Disease, Chronic, Due To Ncf4 Deficiency Chronic Granulomatous Disease 3, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 3 Autosomal Recessive Cytochrome B-Positive Cgd Type Iii Cdg3 Chronic Granulomatous Disease Due To Ncf4 Deficiency Cgd Autosomal Recessive Cytochrome B-Positive Type Iii Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii Granulomatous Disease Chronic Due To Ncf4 Deficiency Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3
Coronin-1a Deficiency
Adenosine Deaminase Deficiency	Ada Deficiency Ada-Scid Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency Adenosine Deaminase Deficient Severe Combined Immunodeficiency Scid Due To Ada Deficiency Severe Combined Immunodeficiency Due To Ada Deficiency Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency Ada Scid Due To Adenosine Deaminase Deficiency
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis
Bare Lymphocyte Syndrome, Type Ii	Mhc Class Ii Deficiency Bare Lymphocyte Syndrome Major Histocompatibility Complex Class Ii Deficiency Bare Lymphocyte Syndrome 2 Bare Lymphocyte Syndrome Type 2 Severe Combined Immunodeficiency, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group C Bare Lymphocyte Syndrome, Type Ii, Complementation Group D Bare Lymphocyte Syndrome Type Ii Scid, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group A Bare Lymphocyte Syndrome, Type Ii, Complementation Group B Scid Due To Absent Class Ii Hla Antigens Hla Class 1 Deficiency Scid, Hla Class 2-Negative Bls Type Ii Bare Lymphocyte Syndrome Type 2, Complementation Group A Bare Lymphocyte Syndrome Type 2, Complementation Group E Severe Combined Immunodeficiency Bls, Type Ii Bls Bare Lymphocyte Syndrome, Type Ii, Complementation Group E Blsii Bls Type 1 Bls 2 Scid Due To Absence Of Class Ii Hla Antigens Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens Immunodeficiency By Defective Expression Of Mhc Class Ii BLS2 Bare Lymphocyte Syndrome Type Ii Complementation Group A Bare Lymphocyte Syndrome Type Ii Complementation Group B Bare Lymphocyte Syndrome Type Ii Complementation Group C Bare Lymphocyte Syndrome Type Ii Complementation Group D Bare Lymphocyte Syndrome Type Ii Complementation Group E Bls Ii Hereditary Mhc Class Ii Deficiency Hla Class Ii Deficient Combined Immunodeficiency Mhc-Ii Deficiency Scid Hla Class Ii-Negative Severe Combined Immunodeficiency Hla Class Ii-Negative Bl-2 Immunodeficiency By Defective Expression Of Hla Class 2 Hla Class 2-Negative Severe Combined Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02242	CD3D Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17740	Cd3d Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24205	Cd3d Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CD3D	VGNC	VGNC:107436
Felis catus	CD3D	VGNC	VGNC:60616
Rattus norvegicus	CD3D	RGD	RGD:2304
Bos taurus	CD3D	VGNC	VGNC:27028
Canis familiaris	CD3D	VGNC	VGNC:38954
Mus musculus	CD3D	MGD	MGI:88331
Others	CD3D	NCBI